An Executive Committee sets the overall direction and strategy for the initiative. A Steering Committee, made up of representatives from CTTI members across multiple sectors, provides input into decisions about CTTI priorities, projects and recommendations. CTTI members also play an important role in facilitating improvements in the design and conduct of clinical trials within their organizations and the overall enterprise. A central staff supports the development and execution of projects and dissemination of project results. In addition, staff members organize and support activities of the Executive and Steering Committees.