Duke University, as the host of CTTI, received a cooperative agreement (U19 FD003800) from the U.S. Food and Drug Administration, followed by the current grant (R18 FD005292), which provides some support for all projects. Member organizations pay an annual fee which supports CTTI infrastructure expenses and projects.

In addition, individuals from many member organizations, and some non-member organizations, contribute time and other resources to make CTTI projects successful.