Large Simple Trials

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Overview

Large simple trials (LSTs) typically answer only one or two questions in a broader patient population and are generally more efficient and less expensive than other large randomized controlled trials. Despite these benefits, LSTs are not often employed due to operational concerns and lack of incentives.  

Read CTTI’s manuscript on solutions for overcoming these barriers, enabling the potential increased efficiency and reduced costs that come with using an LST. 

Solutions

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News

  • Improving Human Health through Large Simple Trials
    “Randomized clinical trials remain the most reliable means of identifying the drugs, devices, and treatment strategies that will improve human health.” – Zubin J. Eapen, MD, MHS, Michael S. Lauer, MD, and ...

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